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    mProX™ Human CALCRL Stable Cell Line

    [CAT#: S01YF-0923-PY27]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
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    Product Information

    Target Protein
    CALCRL
    Target Family
    Calcitonin Family
    Target Protein Species
    Human
    Host Cell Type
    MOLM-14;OCI-AML2;OCI-AML3;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Lymphatic Malformation 8;Hydrops Fetalis, Nonimmune
    Gene ID
    Human: 10203
    UniProt ID
    Human: Q16602

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The Calcitonin Receptor-Like Receptor (CALCRL) has garnered attention in the scientific domain due to its association with various physiological processes. One of the notable findings is its involvement with the adrenomedullin signaling pathway, which has implications in acute myeloid leukemia (AML). Targeting the adrenomedullin-CALCRL axis has been suggested to improve chemotherapy responses in AML models, underscoring its potential as a therapeutic target. Additionally, research has indicated that CALCRL can predict outcomes in AML beyond existing risk factors. Another intriguing aspect of CALCRL research is its role in the lung microenvironment, especially in the context of shock and acute lung injury. The exploration of CALCRL in scientific research has provided valuable insights into its multifunctional roles, from cancer biology to respiratory physiology. Its diverse functions make it a subject of ongoing investigations, with the potential to unveil novel therapeutic strategies for various ailments.

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    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CALCRL Stable Cell Line (S01YF-0923-PY27). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Gary (Verified Customer)

    How does CALCRL contribute to cell proliferation and migration? Oct 21 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CALCRL can activate specific signaling cascades, leading to cell proliferation, migration, and adhesion, especially in the context of trophoblast cells. Oct 21 2020

    chat Patricia (Verified Customer)

    Are there any known receptors or signaling pathways associated with CALCRL? Sep 10 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, the ADM receptor component CALCRL is known to activate the AKT-TSC2-MTOR, particularly the MTORC1 signaling cascade. Sep 10 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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