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    mProX™ Human BTLA Stable Cell Line

    [CAT#: S01YF-1023-PY173]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;H1299
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Rheumatoid Arthritis; Arthritis
    Gene ID
    Human:151888
    UniProt ID
    Human:Q7Z6A9

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    BTLA (B and T lymphocyte attenuator) has applications in various areas of research and medicine. In the context of esophageal squamous cell carcinoma (ESCC), BTLA is identified as one of the cuproptosis-related genes (CRGs) and is used to construct a risk score model to predict the survival and prognosis of patients with ESCC. Additionally, BTLA is shown to be an inhibitory receptor of T cells functions in an immune-infiltrated patient-derived tumor model, suggesting its potential as a target for cancer therapies. In pancreatic cancer, BTLA is found to be correlated with S100P, a potential biomarker for the immunosuppressive microenvironment. Furthermore, in the context of sepsis-induced immunosuppression, artesunate, a drug with immunomodulatory effects, is shown to inhibit the expression of BTLA and promote the MAPK/ERK pathway, leading to increased numbers of T cells and inhibition of T-cell apoptosis. Overall, BTLA is implicated in cancer prognosis, immunotherapy, and modulation of immune responses in different disease contexts.

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    FAQ

    chat Skyler Johnson (Verified Customer)

    What is the role of BTLA in severe community-acquired pneumonia? Sep 28 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    BTLA may be a therapeutic target for severe community-acquired pneumonia, with its expression reflecting the body's immune status and guiding steroid therapy decisions. Sep 28 2022

    chat Peyton Jones (Verified Customer)

    How does BTLA interact with HVEM in immune regulation? Dec 10 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    BTLA exerts significant co-stimulatory effects on B cells through HVEM, influencing immune regulation in health and diseases like systemic lupus erythematosus. Dec 10 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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