mProX™ Human BTK Stable Cell Line
[CAT#: S01YF-1123-KX165]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
BTK
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
AML; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cardiovascular Research; Reproductive Research
Related Diseases
Agammaglobulinemia, X-Linked and Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia. Among its related pathways are MIF Mediated Glucocorticoid Regulation and MyD88 dependent cascade initiated on endosome.
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Humans have a tyrosine kinase called bruton's tyrosine kinase, or tyrosine-protein kinase BTK, which is encoded by the BTK gene. Because it is essential for the receptor to send signals once immunoglobulin heavy chain rearrangement is complete, BTK is important for the formation of B cells. Additionally, it contributes to the activation of mast cells via the high-affinity IgE receptor. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) is bound by the PH domain of Btk. PIP3 binding causes Btk to phosphorylate phospholipase C, which then breaks down PIP2, a phosphatidylinositol, into two second messengers: diacylglycerol (DAG) and inositol triphosphate (IP3). These messengers subsequently influence the function of proteins downstream during B-cell signaling. The customized BTK stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Helen
The BTK cell line was easy to use, and the customer service team was responsive and helpful. Highly recommended!
Nov 17 2022
Verified Customer
Jessica
The technical support team was knowledgeable and provided prompt assistance whenever we had questions. I am extremely satisfied with this BTK overexpression cell line and the overall experience.
May 14 2023
Verified Customer
FAQ
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