mProX™ Human BMX Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 BMX RNAi does not further sensitize PI-103-treated H1048 cells to ABT-737.
BMX mRNA was the target of transfections using SMARTpool siRNA, single siRNA oligos, or nontargeting control (NT). Western blot showing BMX levels in BMX and NT RNAi cells 48 hours post-transfection.
Ref: Potter, Danielle S., et al. "Inhibition of PI3K/BMX cell survival pathway sensitizes to BH3 mimetics in SCLC." Molecular cancer therapeutics 15.6 (2016): 1248-1260.
Pubmed: 27197306
DOI: 10.1158/1535-7163.MCT-15-0885
Research Highlights
The literature study reveals a dearth of studies on BMX biomechanics, specifically concerning rider kinematics of the BMX SX gate start.
Grigg, Josephine, et al. "Literature review: kinematics of the BMX SX gate start." Journal of Science and Cycling 6.1 (2017): 3-10.
By functioning as a negative regulator of PAR1, BMX encourages the internalization of PAR1 and the phosphorylation of PAR1 to inactivate the signal. Furthermore, in early sepsis, BMX-mediated PAR1 internalization prevents vascular leakage by reducing endothelial permeability.
Li, Zhao, et al. "BMX represses thrombin-PAR1-mediated endothelial permeability and vascular leakage during early sepsis." Circulation research 126.4 (2020): 471-485.
Pubmed:
31910739
DOI:
10.1161/CIRCRESAHA.119.315769
