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  • mProX™ Human BDKRB1 Stable Cell Line

    [CAT#: S01YF-0923-PY24]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    BDKRB1
    Target Family
    Bradykinin Family
    Target Protein Species
    Mouse
    Host Cell Type
    RAW264.7;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research;Digestive and Renal Research
    Related Diseases
    End Stage Renal Disease;Covid-19
    Gene ID
    Mouse: 12061
    UniProt ID
    Mouse: Q61125

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Bradykinin Receptor B1 (BDKRB1) has been a focal point in numerous scientific studies due to its role in various physiological processes. One of the intriguing aspects of BDKRB1 is its involvement in the modulation of inflammatory responses. It has been identified that BDKRB1 plays a crucial role in mediating inflammation, especially in conditions where there is tissue injury or infection. This receptor is upregulated during these inflammatory conditions, making it a potential therapeutic target for diseases characterized by inflammation. Moreover, studies have also highlighted the potential role of BDKRB1 in vascular functions, suggesting its involvement in blood pressure regulation. The interaction between BDKRB1 and other systems, such as the angiotensin system, has been explored to understand the intricate balance of vasodilation and vasoconstriction in cardiovascular health. Furthermore, the genetic polymorphisms associated with BDKRB1 have been investigated to understand their potential impact on drug responses, especially in the context of antihypertensive therapies. Overall, the application of BDKRB1 in scientific research spans from understanding basic physiological processes to exploring therapeutic interventions for various diseases.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Kimberly (Verified Customer)

    Are there any known associations between BDKRB1 and diseases or disorders? Jun 14 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, for instance, the BDKRB1 rs12050217 G allele has been associated with protection against the advanced stage of diabetic retinopathy in T2DM patients. Jun 14 2023

    chat Rebecca (Verified Customer)

    How is BDKRB1 related to membrane protein cell lines? Feb 15 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    BDKRB1 is a membrane protein, and its expression and function can be studied using cell lines that express this receptor. These cell lines can help in understanding the receptor's role in inflammation and other cellular processes. Feb 15 2021

    Published Data

    Fig.1 Effect of overexpression of Bdkrb1 gene in RAW264.7 cells on NF-κB activation.

    Plasmids with full cDNAs of specified genes, or a negative control, positioned after a certain promoter, were co-introduced with two other plasmids. Post-transference, cells received a specific stimulation for a set duration, after which their immune reactivity was gauged via luciferase output. Averages from three separate tests, showcasing variability, are illustrated; a delineated threshold highlights a twofold augmentation in a particular immune response due to gene amplification. Statistical significance is denoted for certain comparisons.

    Ref: Alper, Scott, et al. "Novel innate immune genes regulating the macrophage response to Gram positive bacteria." Genetics 204.1 (2016): 327-336.

    Pubmed: 27356610

    DOI: 10.1534/genetics.115.185314

    Research Highlights

    Torres-Mendez JK, et al. "Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent ." Nutrients, 2023.
    In this study, the effects of dietary nicotinamide (NAM) supplementation in treating brain inflammation in type 1 diabetic (T1D) mice were investigated. The T1D mice were divided into three groups: non-treated, low-dose NAM (NAM LD), and high-dose NAM (NAM HD). The results showed that the markers of inflammation and microglial activation were significantly reduced in the NAM-treated mice compared to the non-treated T1D mice. Moreover, the nuclear NFκB (p65) signaling was also alleviated in the NAM-treated diabetic mice. These findings indicate that dietary NAM supplementation can prevent brain inflammation through NAD+-dependent deacetylation mechanisms, possibly through increased sirtuin signaling.
    Pubmed: 37513501   DOI: 10.3390/nu15143083

    Punapart M, et al. "Chronic Stress Alters Hippocampal Renin-Angiotensin-Aldosterone System Component ." Genes, 2023.
    Biallelic mutations in the gene WFS1 have been identified as the cause of Wolfram syndrome (WS), a rare neurodegenerative disorder with no current cure. Previous studies have shown that WFS1 deficiency can disrupt the renin-angiotensin-aldosterone system (RAAS). In a rat model of WS, our team observed downregulation of key receptors in various organs, including angiotensin II receptor type 2 (Agtr2) and bradykinin receptor B1 (Bdkrb1). Our latest research reveals dysregulation of RAAS components in neural tissue from older WS rats, unaffected by treatments such as liraglutide (LIR), 7,8-dihydroxyflavone (7,8-DHF), or a combination of both. Furthermore, we observed decreased expression of angiotensin II receptor type 1a (Agtr1a), angiotensin II receptor type 1b (Agtr1b), Agtr2, and Bdkrb1 in the hippocampus of WS rats experiencing long-term experimental stress. These results suggest that under chronic stress, Wfs1 deficiency impairs RAAS functioning and contributes to neurodegeneration in WS.
    Pubmed: 37107585   DOI: 10.3390/genes14040827

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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