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    mProX™ Human B2M Stable Cell Line

    [CAT#: S01YF-1023-PY189]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;MC-38
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Immunodeficiency 43; Amyloidosis, Familial Visceral
    Gene ID
    Human:567
    UniProt ID
    Human:P61769

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The applications of B2M include identifying potential candidate proteins associated with low bone mineral density in postmenopausal women, genetic ablation of adhesion ligands to prevent rejection of allogeneic immune cells, comparing the senescence-inducing properties of CDK4/6 inhibitors and DNA-damaging agents in breast cancer, screening and validating the optimal panel of reference genes in colonic epithelium and cancer cell lines, and investigating T-cell mediated immune rejection of beta-2-microglobulin knockout induced pluripotent stem cell-derived kidney organoids.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Skyler Williams (Verified Customer)

    How does B2M gene knockout affect natural killer cell cytotoxicity? Sep 15 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Enhanced natural killers with CISH and B2M gene knockouts show increased cytotoxicity in glioblastoma primary cultures, suggesting their potential in immunotherapy. Sep 15 2023

    chat Jordan Miller (Verified Customer)

    What is the impact of B2M expression on cancer immunotherapies? Sep 27 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    B2M overexpression correlates with malignancy, immune signatures, and determines the response to immunotherapy in cancers like gliomas, making it a potential candidate for immunotherapy . Sep 27 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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