mProX™ Human AVPR1B Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Hepatic V1bR potentiates the lipogenic effects of fructose.
V1bR, fructokinase (KHK), and actin representative Western blots and densitometry (n = 2 total blots) in human HepG2 cells Ctrl or subjected to AVP (250 nM), Frct (10 mM), or a combination of Frct plus AVP for 5 days.
Ref: Andres-Hernando, Ana, et al. "Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor." JCI insight 6.1 (2021).
Pubmed: 33320834
DOI: 10.1172/jci.insight.140848
Research Highlights
This study discovered that tumors with USP8 mutations have higher ACTH responsiveness to DDAVP in CD. According to the available data, USP8 mutations increase the activity of the AVPR1B promoter.
Shichi, Hiroki, et al. "Responsiveness to DDAVP in Cushing's disease is associated with USP8 mutations through enhancing AVPR1B promoter activity." Pituitary 25.3 (2022): 496-507.
Pubmed:
35451730
DOI:
10.1007/s11102-022-01220-4
These findings suggest that the hippocampal CA2 is crucial for initiating an assault in response to a male intruder and that the Avpr1b is an essential mediator, most likely due to its function in controlling CA2 synaptic plasticity.
Pagani, Jerome H., et al. "Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2." Molecular psychiatry 20.4 (2015): 490-499.
Pubmed:
24863146
DOI:
10.1038/mp.2014.47
