mProX™ Human AVPR1A Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

A natural, endogenous ligand called arginine vasopressin (AVP) binds to and activates AVPR1A in both the central and peripheral nervous systems. Vasopressin signaling via the arginine vasopressin receptor 1A (AVPR1A) in the brain has been demonstrated to be an important moderator of a wide range of behaviors, including pair-bonding, parental care, aggression, and stress-coping. Reduced anxiety, poor reciprocal social contact, and diminished social recognition were all observed in Avpr1a knockout mice, demonstrating that the receptor plays a significant role in modulating crucial social behaviors. AVPR1A has been linked to a number of pro-social and affiliative activities, but in some species and in some situations, it also promotes processes that may result in anti-social behaviors, such as heightened aggression and anxiety. Therefore, AVPR1A function in rats can be blocked to improve social interactions, most likely via lowering social anxiety. The customized AVPR1A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.