mProX™ Human AVPR1A Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 AVPR1A antagonist, relcovaptan, blocks AVP-mediated calcium flux and ERK/CREB activation in CRPC cells.
The stated AVP concentrations, no (vehicle) treatment (NT), or 100 nM AVP treatments were given to 22Rv1 cells that had been serum-starved for 48 hours. As a positive control, epidermal growth factor (EGF; 10 ng/ml) was used.
Ref: Zhao, Ning, et al. "Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer." Science translational medicine 11.498 (2019): eaaw4636.
Pubmed: 31243151
DOI: 10.1126/scitranslmed.aaw4636
Research Highlights
According to this study, postnatal CS increased AvpR1a expression in HC at a young adult age and caused depressive-like behavior.
Lesse, Alexandra, et al. "Chronic postnatal stress induces depressive-like behavior in male mice and programs second-hit stress-induced gene expression patterns of OxtR and AvpR1a in adulthood." Molecular neurobiology 54 (2017): 4813-4819.
Pubmed:
27525673
DOI:
10.1007/s12035-016-0043-8
This study directly ties an AVPR1A polymorphism to structural variation in the social brain network and is the first to report a connection between AVPR1A and gray matter covariation in nonhuman primates.
Mulholland, Michele M., et al. "AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees." Genes, Brain and Behavior 19.4 (2020): e12631.
Pubmed:
31894656
DOI:
10.1111/gbb.12631
