mProX™ Human ADRA2C Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ADRA2C gene, encoding the alpha-2C adrenergic receptor, has been a subject of interest in various scientific research studies. This receptor is involved in the regulation of neurotransmitter release and plays a crucial role in various physiological processes. Recent studies have highlighted the epigenetic predisposition that differentially modulates ADRA2A and ADRA2C mRNA expression in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia subjects. This modulation is influenced by epigenetic modifications, specifically histone methylation and acetylation in human DLPFC. Furthermore, the ADRA2C gene has been linked to Down's syndrome, a leading cause of disability in young individuals. Additionally, research has indicated that the ADRA2C gene might not be involved in the domestication of the stress response in chickens, despite the presence of a strong selective sweep around the gene. The gene has also been associated with attention-deficit hyperactivity disorder (ADHD), especially in subjects with learning disabilities. In conclusion, the ADRA2C gene has diverse applications in scientific research, ranging from neuropsychiatric disorders to genetic predispositions and animal domestication.