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    mProX™ Human ADORA2B Stable Cell Line

    [CAT#: S01YF-0923-PY4]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    ADORA2B
    Target Family
    Adenosine Family
    Target Protein Species
    Mouse
    Host Cell Type
    LM2;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Digestive and Renal Research
    Related Diseases
    Priapism;Cholera
    Gene ID
    Mouse: 11541
    UniProt ID
    Mouse: Q60614

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Adenosine receptor A2B (ADORA2B) has emerged as a significant receptor in scientific research, particularly in the context of inflammation and cancer. One of the notable findings is its role in the attenuation of cardiac ischemia-reperfusion injury. During such events, the neuronal guidance molecule netrin-1 is released by activated neutrophils, dampening myocardial inflammation by activating ADORA2B receptors on myeloid immune cells. In the context of pulmonary health, co-inhibition of CD73 and ADORA2B has been shown to improve long-term cigarette smoke-induced lung injury. Moreover, in pancreatic cancer, CD73-dependent adenosine signaling through ADORA2B has been identified to drive immunosuppression. These findings highlight the diverse roles of ADORA2B in various physiological and pathological processes, emphasizing its significance in scientific research and potential therapeutic applications.

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    FAQ

    chat David (Verified Customer)

    Are there any known antagonists for ADORA2B? Jun 14 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, there are specific antagonists for ADORA2B that can modulate its activity. Jun 14 2022

    chat Shirley (Verified Customer)

    How does ADORA2B influence cell adhesion? Apr 29 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ADORA2B activation can influence cell adhesion molecules, impacting the adhesion of immune cells to the endothelium. Apr 29 2022

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