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    mProX™ Human ADGRF1 Stable Cell Line

    [CAT#: S01YF-0923-PY161]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    ADGRF1
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    BT474;SKBR3;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Ocular Research
    Related Diseases
    Usher Syndrome, Type Iic;Adie Pupil
    Gene ID
    Human: 266977
    UniProt ID
    Human: Q5T601

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ADGRF1, also known as GPR110, is a receptor that has been associated with various physiological and pathological processes. Recent studies have shown that ADGRF1 can signal through all major G-protein classes, and its structure has been elucidated to understand its Gαq preference. In the realm of oncology, ADGRF1 has been shown to promote tumorigenesis in HER2+ and triple-negative breast cancers by activating the STAT3 pathway. Additionally, ADGRF1 has been identified as playing a role in visual function recovery post-optic nerve injury.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Karen (Verified Customer)

    What is the biological role of ADGRF1? Dec 06 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ADGRF1, also known as GPR110, is an adhesion-GPCR with significant functions in neurodevelopment and cancer. However, its specific coupling to G proteins and downstream pathways in cancer remain to be fully elucidated​​. Dec 06 2022

    chat Amanda (Verified Customer)

    What is the significance of ADGRF1's interaction with tight junction proteins? Apr 07 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The interaction between ADGRF1 and tight junction protein occludin has been implicated in blood-brain barrier permeability, showcasing ADGRF1's potential role in neurobiology and its impact on barrier function between the bloodstream and the central nervous system​​. Apr 07 2021

    Related Products by Target
    • mProX™ Human ADGRF1 Stable Cell Line (CAT#: S01YF-0923-PY161)
    • Magic™ Human FLAG tagged ADGRF1 HEK293T Cell Line, (CAT#: S01YF-1022-KX188)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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