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    mProX™ Human ADGRB3 Stable Cell Line

    [CAT#: S01YF-0223-KX3]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    ADGRB3
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    MB; CHO-K1; HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cardiovascular Research; CNS Research; Orphan Receptor Research
    Related Diseases
    Carey-Fineman-Ziter Syndrome; Polymicrogyria; Bilateral Frontoparietal
    Gene ID
    577
    UniProt ID
    O60242

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ADGRB3 is a member of the adhesion G protein-coupled receptor (adhesion GPCR) subfamily, which is important in the control of a number of CNS processes, including axon guidance, myelination, and synapse development and function. ADGRB3 is similarly extensively expressed in the cerebellum, and ADGRB1 and ADGRB3 are concentrated in the postsynaptic density. ADGRB3 interacts with C1q3, another secreted protein that is particular to the brain, to regulate synapse density in hippocampal neurons where it is also highly expressed. In fact, mice with hippocampus neurons lacking ADGRB3 exhibit severely impaired dendritic formation. It's interesting to note that ADGRB3 has already been linked to drug addiction, bipolar disorder, and schizophrenia. The customized ADGRB3 stable cell line can be employed in the discovery and development of antibodies, signaling pathway researches, as well as the screening of potential therapeutic candidates.

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    FAQ

    chat William (Verified Customer)

    Can you provide tips to reduce the background noise? Mar 08 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Use healthy cells that have been passaged at least 24 hours before to the assay.
    Don't let the cells reach 80% confluence.
    Don't put too many cells in each well.     Mar 08 2023

    chat John (Verified Customer)

    What freezing medium should be used for this cell line? Mar 23 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    The use of frozen culture depends on the host cell type. For adherent cells, we recommend DMEM, 20% (v/v) fetal bovine serum (FBS), and 10% (v/v) DMSO. For suspension cells, we recommend fetal bovine serum (FBS) and 10% DMSO. Mar 23 2023

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    • mProX™ Human ADGRB3 Stable Cell Line (CAT#: S01YF-0223-KX3)
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