mProX™ Human ADGRB2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 ADGRB2 can activate Gi/o/z proteins.
The ECM and ADGRB2 interact to activate the Gi/o/z proteins. ADGRB2 stimulates intracellular GABP and VEGF in the dentate gyrus of the hippocampus, increasing neurogenesis.
Ref: Watkins, Lyndsay R., and Cesare Orlandi. "Orphan G protein coupled receptors in affective disorders." Genes 11.6 (2020): 694.
Pubmed: 32599826
DOI: 10.3390/genes11060694
Research Highlights
A promising in vitro option for the identification of STX-like toxins is the Neuro-2a cell test.
Rivera, A. A., et al. Search for potential biomarkers for saxitoxin detection. Toxicology in Vitro. 2021, 72, 105092.
Pubmed:
33440187
DOI:
10.1016/j.tiv.2021.105092
The primary mediators of signal transduction in the central nervous system are G protein coupled receptors (GPCRs). Numerous GPCRs have long been studied to determine how they contribute to the emergence of anxiety and mood disorders as well as how antidepressant medications work.
Watkins, L. R., Orlandi, C. Orphan G protein coupled receptors in affective disorders. Genes. 2020, 11(6), 694.
Pubmed:
32599826
DOI:
10.3390/genes11060694
