mProX™ Human ABCC1 Stable Cell Line

[CAT#: S01YF-1123-KX118]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Transporter Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-0922-KX1557	Magic™ Human ABCC1 in Vitro Drug screening assay	Human	Caco-2, MDCK, HEK293, CHO, membrane vesicles, and various transfected cells lines	Activity Assay (High throughput screening assays; Large scale single dose, duplicate profiling; IC50 profiling; Ki determination assay; Substrate determination assay )

Product Information

Target Protein

ABCC1

Target Family

ABC Transporter

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Transporter Cell Lines

Target Research Area

Auditory and Otology Research

Related Diseases

Deafness; Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Gene ID

4363

UniProt ID

P33527

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Numerous chemotherapeutic drugs and conjugates of glutathione, glucuronide, and sulfate are among the many organic anions that human ABCC1 transports. By facilitating leukotriene-mediated inflammatory responses, defending against oxidative stress by extruding GSSG from cells, and shielding human bodies against toxic endobiotics and xenobiotics, ABCC1 is a multifunctional GS-X pump. These activities also establish ABCC1's crucial role in MDR in the chemotherapy of various cancers. Several in vivo and in vitro investigations have shown that ABCC1 downregulation causes various anticancer medications, which are ABCC1 substrates, to become chemosensitized. This suggests that human ABCC1 is a viable target for reversing MDR in a variety of cancer types. The customized ABCC1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Richard

This ABCC1 KD cell line has saved us time and resources. Our team is excited to delve deeper into our investigations with this versatile tool. Jul 13 2022

chat Verified Customer

chat Helen

I think this mouse ABCC1 cell line is better than many similar products already on the market. Jun 04 2020

chat Verified Customer

FAQ

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