Human KCNQ2 Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX301]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein mRNA
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order LNP-mRNA encoding human KCNQ2.
Target Protein
KCNQ2
Target Protein Species
Human
Target Classificationp
Ion Channel
Target Research Area
Auditory and Otology Research; CNS Research
Related Diseases
Developmental And Epileptic Encephalopathy; Seizures, Benign Familial Neonatal; Benign Familial Neonatal Epilepsy
Target Family
Voltage Gated Potassium Channel
RNA Type
LNP-mRNA
Nucleoside Modification Method
m1Ψ; m5C or specific requirements
Cap
Cap 0; Cap 1 or specific requirements
PolyA Tail (nt)
30 nt; 80 nt; 120 nt or specific requirements
5' UTR
Human globin alpha; 5' UTR seq can be modified according to the specific requirements
Promoter
T7
Tag
Based on specific requirements
Fluorescent Markers
Based on specific requirements
Formation
LNP Encapsulation mRNA
LNP Formulation
Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
Buffer
Tris buffer or PBS
Quality Control
OD260/280 (~1.90-2.50)
PASS
Agarose Gel Mobility
PASS
Sequence and Enzyme Digestion
PASS
Encapsulation Efficiency
PASS
mRNA Transfection Efficiency
PASS
Product Properties
Application
Drug discovery research and pre-clinical studies
Shipping
Blue Ice
Storage
Aliquot and store at 2-8°C for long term.
Target
Full Name
Potassium voltage-gated channel subfamily Q member 2
Introduction
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Alternative Names
EBN; BFNC; DEE7; EBN1; ENB1; HNSPC; KV7.2; KCNA11; potassium voltage-gated channel subfamily KQT member 2; neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; voltage-gated potassium channel subunit Kv7.2; KCNQ2; Potassium voltage-gated channel subfamily Q member 2
Gene ID
UniProt ID
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