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  • Human JAK2 Membrane Protein In Vitro Transcription (IVT) Plasmid

    [CAT#: S01YF-1124-KX1105]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein Plasmid Products

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    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order plasmid encoding human JAK2 for In Vitro Transcription.
    Target Protein
    JAK2
    Target Protein Species
    Human
    Target Classification
    Kinases/Enzyme
    Target Research Area
    Cardiovascular Research
    Related Diseases
    Polycythemia Vera; Thrombocythemia
    Target Family
    Kinases/Enzyme
    Vector
    pIVT
    Vector Type
    In Vitro Transcription (IVT) Vector
    Note
    Resistance
    KanR
    Growth Temperature
    37°C
    Relevant Promoters
    T7
    Mutation
    Based on specific requirements
    Expressed Tags
    Based on specific requirements (Flag, StrepII, His, etc.)

    Product Properties

    Applications
    In Vitro Transcription
    Shipping
    Blue Ice
    Storage
    Aliquot and store at -20°C for long term.

    Target

    Full Name
    Janus kinase 2
    Introduction
    This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Alternative Names
    JTK10; tyrosine-protein kinase JAK2; JAK-2; Janus kinase 2 (a protein tyrosine kinase)
    Gene ID
    UniProt ID

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