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  • Human JAK2 Membrane Protein LNP Encapsulation mRNA

    [CAT#: S01YF-1124-KX300]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein mRNA

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    Certificate of Analysis Lookup
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    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order LNP-mRNA encoding human JAK2.
    Target Protein
    JAK2
    Target Protein Species
    Human
    Target Classificationp
    Kinases/Enzyme
    Target Research Area
    Cardiovascular Research
    Related Diseases
    Polycythemia Vera; Thrombocythemia
    Target Family
    Kinases/Enzyme
    RNA Type
    LNP-mRNA
    Nucleoside Modification Method
    m1Ψ; m5C or specific requirements
    Cap
    Cap 0; Cap 1 or specific requirements
    PolyA Tail (nt)
    30 nt; 80 nt; 120 nt or specific requirements
    5' UTR
    Human globin alpha; 5' UTR seq can be modified according to the specific requirements
    Promoter
    T7
    Tag
    Based on specific requirements
    Fluorescent Markers
    Based on specific requirements
    Formation
    LNP Encapsulation mRNA
    LNP Formulation
    Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
    Buffer
    Tris buffer or PBS

    Quality Control

    OD260/280 (~1.90-2.50)
    PASS
    Agarose Gel Mobility
    PASS
    Sequence and Enzyme Digestion
    PASS
    Encapsulation Efficiency
    PASS
    mRNA Transfection Efficiency
    PASS

    Product Properties

    Application
    Drug discovery research and pre-clinical studies
    Shipping
    Blue Ice
    Storage
    Aliquot and store at 2-8°C for long term.

    Target

    Full Name
    Janus kinase 2
    Introduction
    This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Alternative Names
    JTK10; tyrosine-protein kinase JAK2; JAK-2; Janus kinase 2 (a protein tyrosine kinase)
    Gene ID
    UniProt ID

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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