Human CD274 Membrane Protein Retroviral Expression Plasmid
[CAT#: S01YF-1124-KX936]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein Plasmids
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order plasmid encoding human CD274 for Retrovirus Production.
Target Protein
CD274
Target Protein Species
Human
Target Classification
Immune Checkpoint
Target Research Area
Autoimmune Research; Cancer Research; Immunology Research
Related Diseases
Lymphoepithelioma-Like Carcinoma; Pleomorphic Carcinoma
Target Family
Immune Checkpoint
Vector
pRV
Vector Type
Retroviral Expression Vector
Note
Resistance
AmpR
Growth Temperature
37°C
Relevant Promoters
CMV, SV40, EF1a, CAG etc.
Mutation
Based on specific requirements
Expressed Tags
Based on specific requirements (Flag, StrepII, His, etc.)
Fluorescent Markers
EGFP, mCherry etc.
Selection Markers
Puromycin, Hygromycin, Neomycin, Blasticidin etc.
Product Properties
Applications
Retrovirus Production
Shipping
Blue Ice
Storage
Aliquot and store at -20°C for long term.
Target
Full Name
CD274 molecule
Introduction
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Alternative Names
CD274; B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; CD274 molecule
Gene ID
UniProt ID
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