TTK
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
| Full Name | TTK protein kinase |
| Gene ID | Human: 7272 Mouse: 22137 Rat: 315852 Monkey: 718430 |
| UniProt ID | Human: P33981 Mouse: P35761 Rat: D4A4S7 Monkey: Q4R945 |
| Alternative Names | ESK; PYT; CT96; MPH1; MPS1; MPS1L1;dual specificity protein kinase TTK;cancer/testis antigen 96;monopolar spindle 1 kinase;monopolar spindle 1-like 1;phosphotyrosine picked threonine kinase;phosphotyrosine picked threonine-protein kinase |
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mProX™ Human TTK Stable Cell Line
[CAT#: S01YF-1023-PY124]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;HGC-27
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