PLK3
The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis.
| Full Name | polo like kinase 3 |
| Gene ID | Human: 1263 Mouse: 12795 Rat: 58936 Monkey: 704071 |
| UniProt ID | Human: Q9H4B4 Mouse: Q60806 Rat: Q9R011 |
| Alternative Names | CNK; FNK; PRK; PLK-3;serine/threonine-protein kinase PLK3;FGF-inducible kinase;cytokine-inducible serine/threonine-protein kinase;proliferation-related kinase |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: PLK3 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;DU145 Assay Types: Biological assays
