PAK1
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
| Full Name | p21 (RAC1) activated kinase 1 |
| Gene ID | Human: 5058 Mouse: 18479 Rat: 29431 Monkey: 698585 |
| UniProt ID | Human: Q13153 Mouse: O88643 Rat: P35465 |
| Alternative Names | IDDMSSD; p65-PAK; PAKalpha; alpha-PAK;serine/threonine-protein kinase PAK 1;STE20 homolog, yeast;p21 protein (Cdc42/Rac)-activated kinase 1;p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast);p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) |
Product List
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mProX™ Human PAK1 Stable Cell Line
[CAT#: S01YF-1023-PY40]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;A549;LK-2
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