MAPK14
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
| Full Name | mitogen-activated protein kinase 14 |
| Gene ID | Human: 1432 Mouse: 26416 Rat: 81649 Monkey: 718976 |
| UniProt ID | Human: Q16539 Mouse: P47811 Rat: P70618 |
| Alternative Names | RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA;mitogen-activated protein kinase 14;CSAID-binding protein;MAP kinase 14;MAP kinase Mxi2;MAP kinase p38 alpha;MAX-interacting protein 2;cytokine suppressive anti-inflammatory drug binding protein;mitogen-activated protein kinase p38 alpha;p38 MAP kinase;p38 mitogen activated protein kinase;p38alpha Exip;stress-activated protein kinase 2A |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAPK14 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;ACHN;Caki-1 Assay Types: Biological assays
