LILRB4
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
| Full Name | Leukocyte immunoglobulin like receptor B4 |
| Gene ID | Human: 11006 Rat: 292594 Monkey: 692336 |
| UniProt ID | Human: Q8NHJ6 Mouse: Q64281 Rat: Q67EV3 Monkey: F6PYW3 |
| Alternative Names | LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5; leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; monocyte inhibitory receptor HM18; Leukocyte immunoglobulin like receptor B4 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Cyno Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: C1498 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Human Host Cell Type: CHO-S Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Target Family: Oncology Target Protein Species: Human Host Cell Type: MC-38 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB4 Host Cell Type: A549
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Oncology Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;THP-1
