IL4R
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
| Full Name | Interleukin 4 receptor |
| Gene ID | Human: 3566 Mouse: 110299093 Rat: 25084 Monkey: 705404 |
| UniProt ID | Human: P24394 Mouse: P16382 Rat: Q63257 Monkey: F6RUR0 |
| Alternative Names | CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; interleukin 13 receptor; interleukin-4 receptor alpha chain |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: IL4R & IL13Ra Target Family: Immune Checkpoint Target Protein Species: Cyno Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: IL4R & IL13Ra Target Family: Immune Checkpoint Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: IL4R & IL13Ra Target Family: Immune Checkpoint Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: IL4R Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: CHO-S Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;R221a;4T1 Assay Types: Biological assays
