FGFR3
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
| Full Name | fibroblast growth factor receptor 3 |
| Gene ID | Human: 2261 Mouse: 14184 Rat: 84489 Monkey: 712829 |
| UniProt ID | Human: P22607 Mouse: Q61851 Rat: F1LSN4 |
| Alternative Names | ACH; CEK2; JTK4; CD333; HSFGFR3EX;fibroblast growth factor receptor 3;FGFR-3;fibroblast growth factor receptor 3-S;hydroxyaryl-protein kinase;tyrosine kinase JTK4 |
Product List
Loading...
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 & BAIAP2L1 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 & TACC3 (K650E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 & TACC3 (K650M) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 & TACC3 (K650Q) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 & TACC3 (V555M) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 & TACC3 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3; pGL4.30 Target Family: Receptor Tyrosine Kinases Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3; pGL4.30 Target Family: Receptor Tyrosine Kinases Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR3 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: PDAC; CHO-K1; HEK293
