ERBB4
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
| Full Name | Erb-b2 receptor tyrosine kinase 4 |
| Gene ID | Human: 2066 Mouse: 13869 Rat: 59323 Monkey: 693341 |
| UniProt ID | Human: Q15303 Mouse: Q61527 Rat: Q62956 Monkey: A0A2K5W0D3 |
| Alternative Names | ERBB4; HER4; ALS19; p180erbB4; receptor tyrosine-protein kinase erbB-4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; human epidermal growth factor receptor 4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; Erb-b2 receptor tyrosine kinase 4 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB4 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB4 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: CHO Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB4 (E452K) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
