BRAF
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
| Full Name | B-Raf proto-oncogene, serine/threonine kinase |
| Gene ID | Human: 673 Mouse: 109880 Rat: 114486 Monkey: 693554 |
| UniProt ID | Human: P15056 Mouse: P28028 Rat: F1M9C3 |
| Alternative Names | NS7; B-raf; BRAF1; RAFB1; B-RAF1; BRAF-1;serine/threonine-protein kinase B-raf;94 kDa B-raf protein;B-Raf proto-oncogene serine/threonine-protein kinase (p94);B-Raf serine/threonine-protein;murine sarcoma viral (v-raf) oncogene homolog B1;proto-oncogene B-Raf;v-raf murine sarcoma viral oncogene homolog B;v-raf murine sarcoma viral oncogene homolog B1 |
Product List
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Magic™ Human BRAF (V600, K601delinsE) BaF3 Cell Line
[CAT#: S01YF-1222-KX592]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (V600, K601delinsE) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF (T599, V600insT) BaF3 Cell Line
[CAT#: S01YF-1222-KX593]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (T599, V600insT) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF (N486, P490del, K547Q) BaF3 Cell Line
[CAT#: S01YF-1222-KX591]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (N486, P490del, K547Q) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF (K601N) BaF3 Cell Line
[CAT#: S01YF-1222-KX590]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (K601N) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF (G469A) BaF3 Cell Line
[CAT#: S01YF-1222-KX628]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (G469A) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF & AGAP3 BaF3 Cell Line
[CAT#: S01YF-1222-KX589]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF & AGAP3 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF (V600R) BaF3 Cell Line
[CAT#: S01YF-0324-KX161]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (V600R) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BRAF (V600K) BaF3 Cell Line
[CAT#: S01YF-0324-KX160]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (V600K) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BRAF (V600E) BaF3 Cell Line
[CAT#: S01YF-1222-KX807]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (V600E) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human KIAA1549 & BRAF BaF3 Cell Line
[CAT#: S01YF-0324-KX200]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KIAA1549 & BRAF Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
mProX™ Human BRAF Stable Cell Line
[CAT#: S01YF-1123-KX161]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: RKO; CHO-K1; HEK293
Magic™ Human BRAF (L597R) BaF3 Cell Line
[CAT#: S01YF-0324-KX159]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (L597R) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BRAF (K601E) BaF3 Cell Line
[CAT#: S01YF-0324-KX158]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF (K601E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BRAF & MAD1L1 BaF3 Cell Line
[CAT#: S01YF-1222-KX757]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF & MAD1L1 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BRAF & AGK BaF3 Cell Line
[CAT#: S01YF-1222-KX587]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BRAF & AGK Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
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