BCAR1
The protein that this gene produces belongs to the family of scaffold proteins known as Crk-associated substrate (CAS), which is distinguished by the presence of several protein-protein interaction domains and numerous serine and tyrosine phosphorylation sites. The encoded protein has a bipartite Src-binding domain that can bind both SH2 and SH3 domains, a proline-rich domain, a substrate domain with 15 repeats of the YxxP consensus phosphorylation motif, a serine-rich region, and a Src homology 3 (SH3) domain. Cell motility, apoptosis, and cell cycle regulation are just a few of the several biological pathways in which this adaptor protein participates. This gene's dysregulation can affect many distinct pathways, including endothelium migration, cancer, vascular smooth muscle cells, liver and kidney function, and cardiac development.
| Full Name | BCAR1 scaffold protein, Cas family member |
| Gene ID | Human: 9564 Mouse: 12927 Rat: 25414 Monkey: 713965 |
| UniProt ID | Human: P56945 Mouse: Q61140 Rat: Q63767 Monkey: A0A2K6UJF0 |
| Alternative Names | CAS; CAS1; CASS1; CRKAS; P130Cas; breast cancer anti-estrogen resistance protein 1; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; Cas scaffolding protein family member 1; Crk-associated substrate p130Cas |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCAR1 Target Family: Calcium Sensor Family Target Protein Species: Human Host Cell Type: H1299;H1975;A549;CHO-K1;HEK293
