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    mProX™ Mouse ADGRA1 Stable Cell Line

    [CAT#: S01YF-1023-PY307]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Mouse
    Host Cell Type
    Neuro2A;CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research;Ocular Research
    Related Diseases
    Usher Syndrome, Type Iic;Cortical Dysplasia, Complex, With Other Brain Malformations 14A
    Gene ID
    Human:84435
    UniProt ID
    Human:Q86SQ6

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Adhesion G protein-coupled receptor A1 (ADGRA1) has been identified as a significant player in various physiological processes. Recent research has revealed an essential suppressive role of ADGRA1 in anxiety control and synaptic function by regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways in the amygdala of male mice, suggesting its potential therapeutic application in novel anti-anxiety drug development. Additionally, ADGRA1 has been found to negatively regulate energy expenditure and thermogenesis through both the sympathetic nervous system and the hypothalamus-pituitary-thyroid axis in male mice, emphasizing its role in maintaining metabolic homeostasis.

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    FAQ

    chat Amanda (Verified Customer)

    How does ADGRA1 regulate energy expenditure and thermogenesis in male mice? Feb 26 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ADGRA1 negatively regulates energy expenditure and thermogenesis through both the sympathetic nervous system and the hypothalamus-pituitary-thyroid axis in male mice. An Adgra1-deficient mouse model has been used to study its central function and physiological significance. Feb 26 2022

    chat Kathleen (Verified Customer)

    What is the role of ADGRA1 in the classification of adhesion G protein-coupled receptors? Feb 20 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ADGRA1, also known as GPR123, is classified under the adhesion G protein-coupled receptors (aGPCRs). These receptors have diverse roles in various physiological processes and are characterized by their long N-termini with multiple domains. Feb 20 2023

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    • mProX™ Mouse ADGRA1 Stable Cell Line (CAT#: S01YF-1023-PY307)
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