mProX™ Human YES1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

YES1, a tyrosine-protein kinase, has been implicated in various biological processes and diseases. In the context of intestinal stem cell (ISC) homeostasis, YES1 is involved in the regulation of actin polymerization, which affects ISC proliferation and differentiation. Inhibition of actin polymerization by targeting the ARPC2 protein leads to changes in ISC behavior and intestinal epithelial cell migration. In lung adenocarcinoma, YES1 is associated with the ASCL1-positive subtype, where it regulates the expression of microRNAs and the suppression of ZFP36L1, a target gene of miR-124-3p. In small-cell lung carcinoma, YES1 is one of the proteins used to classify molecular subtypes, along with ASCL1, NEUROD1, POU2F3, and YAP1. In osteoporosis, extracellular vesicles derived from bone marrow mesenchymal stem cells deliver YES1 and stabilize YAP1 protein, leading to activation of the Wnt/β-catenin pathway and promotion of bone formation. Finally, in the context of epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp, YES1 is upregulated in T cells and may play a role in mediating the cutaneous adverse reaction. Overall, YES1 has diverse applications in various biological processes and diseases, including stem cell homeostasis, cancer, bone regeneration, and drug-induced skin reactions.