mProX™ Human WNK3 Stable Cell Line

[CAT#: S01YF-1023-PY132]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX527	Magic™ Human WNK3 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;H2009;H460

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research

Related Diseases

Motor Stereotypies; Sleep Apnea

Gene ID

Human:65267

UniProt ID

Human:Q9BYP7

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The applications of WNK3 include its role in osmosensing and hydrostatic pressure sensing. WNK3 is regulated by chloride, osmotic stress, and hydrostatic pressure, and it functions as an allosteric inhibitor of WNK kinases. Crystallography studies have shown that WNK3 is stabilized by a conserved water network and a cluster of charged residues. Mutations in these residues can enhance WNK3 activity. WNK3 has also been implicated in testis cell pyroptosis and the pathogenesis of Sertoli cell-only syndrome. Additionally, WNK3 interacts with Cullin 3 and is involved in cerebral ischemia-reperfusion injury. High-throughput screening has identified WNK isoform-specific inhibitors, which may have therapeutic potential for hypertension and cancer.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Jones (Verified Customer)

How does WNK3 maintain neuronal excitability? May 12 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

WNK3 kinase maintains neuronal excitability by regulating inwardly rectifying K+ conductance in neurons, impacting sensorimotor gating. May 12 2023

chat Alex Williams (Verified Customer)

Can WNK3 inhibition enhance antitumor immunity? Jul 16 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibition of WNK3 suppresses PD-L1 expression on tumor cells and activates T-cell function, suggesting its potential in cancer immunotherapy. Jul 16 2021

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