mProX™ Human WNK2 Stable Cell Line

[CAT#: S01YF-1023-PY131]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Bulk Quote

Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX526	Magic™ Human WNK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HT29

Target Classification

Kinase Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Hypomagnesemia 4, Renal; Suprasellar Meningioma

Gene ID

Human:65268

UniProt ID

Human:Q9Y3S1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

WNK2 (With no Lysine [K] kinase 2) has various applications in different fields. In the field of ion homeostasis and cell volume regulation, overactivation of WNK2 can lead to pseudohypoaldosteronism type II (Gordon syndrome) characterized by hyperkalemia and high blood pressure. WNK2 has also been shown to be required for the development of the nervous system in mice, zebrafish, and flies, as well as the cardiovascular system of mice and fish. Additionally, WNK2 and its homolog in Drosophila (Wnk) modulate canonical Wnt signaling. The C-terminal domain of WNK2, which has been shown to promote phase transitions in cell culture, is required for viability in vivo. Furthermore, WNK2 has been identified as a potential germline mutation associated with serrated polyposis syndrome, and it has been implicated in the progression of clear cell renal carcinoma. These findings suggest that WNK2 plays diverse roles in various biological processes and diseases, making it a promising target for further research and potential therapeutic interventions.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human WNK2 Stable Cell Line (S01YF-1023-PY131). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Skyler Brown (Verified Customer)

Could WNK2 mutations be associated with serrated polyposis syndrome? Sep 05 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Germline mutations in WNK2 have been identified in cases of serrated polyposis syndrome, suggesting a potential association. Sep 05 2021

chat Casey Johnson (Verified Customer)

How does WNK2 affect ovarian cancer progression? Nov 06 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

WNK2 is targeted by microRNA-324-3p, which suppresses ovarian cancer progression by inhibiting the WNK2/RAS pathway. Nov 06 2021

Related Products by Target

Online Inquiry

Thank you for your interest in mProX™ Human WNK2 Stable Cell Line. Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):

Estimated delivery time for your area;
Product sample or exclusive offer;
In-lab demonstration;

Creative Biolabs does not share your email address with third parties. Creative Biolabs will use your email address to confirm your identity and send you transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.