mProX™ Human WEE1 Stable Cell Line

[CAT#: S01YF-1023-PY129]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX524	Magic™ Human WEE1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;NCI-H322

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Ciliary Dyskinesia, Primary, 20; Vulva Cancer

Gene ID

Human:7465

UniProt ID

Human:P30291

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

WEE1 is a protein kinase that has applications in various cancer treatments. In lung adenocarcinoma, WEE1 inhibition, in combination with E2F8 knockdown, has been shown to suppress cancer cell proliferation and promote apoptosis. In bladder cancer, a nanoparticle loaded with a WEE1 inhibitor and a platinum prodrug has been designed to stimulate the STING pathway, modify the immunosuppressive microenvironment, and increase the response rate to immune checkpoint blockers. In ovarian cancer, targeting WEE1 has shown promising signs of activity in increasing the sensitivity of homologous recombination proficiency tumors to poly (ADP-ribose) polymerase inhibitors. In clear cell ovarian cancer, combining a BRD4 inhibitor with ATR or WEE1 inhibitors has been found to be synergistic and effective in treating ARID1A-deficient tumors. In T lymphoblastic leukemia, bortezomib, a proteasome inhibitor, has been shown to induce DNA damage, downregulate WEE1, and cause mitotic catastrophe, suggesting its potential as a treatment for T-ALL.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Garcia (Verified Customer)

What is the role of WEE1 in the DNA damage response? Jun 08 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

WEE1 kinase is a crucial regulator in the DNA damage response, and its inhibition, combined with genotoxic agents, offers a therapeutic strategy in cancer treatment. Jun 08 2023

chat Alex Davis (Verified Customer)

How does WEE1 contribute to the stability of stalled DNA replication forks? Jul 20 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity, which is crucial for safeguarding DNA replication initiation. Jul 20 2023

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