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    mProX™ Human VSIR Stable Cell Line

    [CAT#: S01YF-1023-PY185]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;MDA-MB-468
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Hard Palate Cancer
    Gene ID
    Human:64115
    UniProt ID
    Human:Q9H7M9

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    V-domain immunoglobulin suppressor of T-cell activation (VISTA) is an immune checkpoint protein that plays a role in immunoregulation. It has been found to have applications in various diseases, including systemic lupus erythematosus (SLE), melanoma, adenocarcinoma, and neuroendocrine tumors. In SLE, VISTA deficiency exacerbates the disease, while enhancing VISTA function through small-molecule agonists like imatinib and M351-0056 can ameliorate SLE development. In melanoma and adenocarcinoma murine models, blocking VISTA with antibodies or genetic knockout combined with radiation therapy improves tumor control ability. In neuroendocrine tumors, VISTA is associated with tumor pathophysiology, and its blockade may have potential therapeutic implications. Additionally, VISTA expression has been studied in triple-negative breast cancer and malignant uveal melanoma, where it is associated with prognosis and may serve as a marker for immunotherapy response. Overall, VISTA has emerged as an important target for therapeutic interventions in various diseases.

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    FAQ

    chat Alex Brown (Verified Customer)

    What is the role of VSIR in cancer immunotherapy? Oct 29 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    VSIR (V-domain Ig suppressor of T cell activation) plays a significant role in the tumor microenvironment, influencing clinical outcomes and tumor immunity in various cancers. Therapeutic strategies targeting VSIR may offer valuable tools for cancer immunotherapy. Oct 29 2023

    chat Morgan Miller (Verified Customer)

    How does VSIR expression affect prognosis in acute myeloid leukemia? Jan 01 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The prognostic value of VSIR in acute myeloid leukemia and myelodysplastic syndromes is debated, with its expression showing conflicting roles in cancer immunity. Jan 01 2022

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