mProX™ Human VRK2 Stable Cell Line

[CAT#: S01YF-1023-PY128]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX523	Magic™ Human VRK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

Kinase Cell Lines

Target Research Area

Infectious Research

Related Diseases

Vaccinia; Pontocerebellar Hypoplasia, Type 8

Gene ID

Human:7444

UniProt ID

Human:Q86Y07

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

VRK2 (vaccinia-related kinase 2) has been implicated in various biological processes and diseases. In hepatocellular carcinoma (HCC), elevated expression of FBXL6 in hepatocytes activates VRK2, leading to immune evasion and liver cancer metastasis. VRK2 also plays a role in the association between epilepsy and COVID-19, with genetic liability to COVID-19 infection, hospitalization, and severity conferring a causal effect on epilepsy and its subtypes. Additionally, reduced expression of VRK2 is associated with a higher risk of depression in humans and mediates depressive-like behaviors in mice. In male transgenic mice, elevated FBXW10 drives HCC tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination. These findings suggest that VRK2 is involved in immune evasion, cancer metastasis, epilepsy, and depression, highlighting its potential as a therapeutic target in these diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Miller (Verified Customer)

What is the therapeutic potential of targeting VRK1 in VRK2-deficient glioblastoma? Nov 11 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibiting VRK1 kinase activity has been proposed as a viable therapeutic strategy in VRK2-methylated glioblastoma, offering a new approach for treatment. Nov 11 2022

chat Skyler Miller (Verified Customer)

What role does VRK2 play in pancreatic cancer? Apr 21 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

VRK2 promotes the progression of pancreatic cancer by activating the TNFα/NF-κB signaling pathway, making it a potential therapeutic target. Apr 21 2021

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