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    mProX™ Human TREM1 Stable Cell Line

    [CAT#: S01YF-1023-PY292]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;AST;BV-2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Orphan Receptor Research
    Related Diseases
    Maxillary Sinusitis; Pneumonia
    Gene ID
    Human:54210
    UniProt ID
    Human:Q9NP99

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TREM1 (triggering receptor expressed on myeloid cells 1) has been identified as a potential therapeutic target in various diseases. In Crohn's Disease (CD) patients who do not respond to anti-TNF therapy, TREM1, along with other genes such as IL1B, CCL4, CXCL1, CXCL10, CCL3, CSF3, and IL1RN, has been identified as a potential target for subsequent treatment. In autoimmune and genetic demyelinating neuropathies, TREM1 is part of the pathogenic pathway associated with nerve demyelination. In patients with COVID-19, TREM1 and TREM2 have been found to be upregulated and may serve as potential diagnostic biomarkers and therapeutic targets. In acute kidney injury (AKI), targeting TREM1 and NLRP3/BNIP3L in platelets may represent a novel therapeutic strategy. Additionally, L-theanine has been shown to regulate immunity and protein metabolism through the FABP5/IL-6/STAT3/PPARα pathway, with the involvement of the EPHX2/IκBα/TREM1 axis.

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    FAQ

    chat Cameron Jones (Verified Customer)

    What role does TREM1 play in inflammatory responses? Apr 11 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TREM1 is involved in amplifying inflammatory responses. For instance, in macrophages, TREM1 expression can induce inflammatory responses, contributing to conditions like thoracic aortic aneurysm and dissection. Apr 11 2020

    chat Cameron Davis (Verified Customer)

    Can TREM1 expression be linked to disease progression in cancer? Sep 08 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, elevated TREM1 expression has been associated with disease progression in cancers like renal cell carcinoma, indicating its role in tumor-associated inflammation. Sep 08 2022

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    • Magic™ Human TREM1 & DAP12 HEK293T Cell Line (CAT#: S01YF-0123-KX123)
    • mProX™ Human TREM1 Stable Cell Line (CAT#: S01YF-1023-PY292)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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