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  • mProX™ Human TPBG Stable Cell Line

    [CAT#: S01YF-1023-PY291]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;PANC-1;BxPC-3
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Metabolic Research
    Related Diseases
    Congenital Disorder Of Glycosylation, Type Il; Renal Cell Carcinoma, Nonpapillary
    Gene ID
    Human:7162
    UniProt ID
    Human:Q13641

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TPBG, or trophoblast glycoprotein, has been identified as a potential biomarker and therapeutic target in various diseases. In coronary artery disease (CAD), TPBG is one of the hub genes associated with hypoxia and immune-related processes. In breast cancer, TPBG is involved in intercellular communication through exosomal circRNA and is associated with cancer progression. In the development of human-induced pluripotent stem cell-derived neural stem cells, TPBG is found to be elevated and plays a critical role in differentiation. In Parkinson's disease, TPBG is identified as a potential genetic biomarker and is strongly related to immune cell infiltration. In renal cell carcinoma, TPBG is highly expressed and can be detected using immunohistochemistry, making it a potential prognostic biomarker and target for immunotherapies. These findings highlight the diverse applications of TPBG in different diseases and provide insights into its potential as a therapeutic target and diagnostic biomarker.

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    FAQ

    chat Peyton Miller (Verified Customer)

    What is the distribution of TPBG in the retina? Jan 21 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TPBG is differentially expressed in the mouse retina, with its C-terminal epitope being blocked in certain conditions, suggesting its involvement in retinal processes. Jan 21 2022

    chat Alex Jones (Verified Customer)

    How does TPBG influence pericyte migratory and angiogenic activity? Oct 06 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TPBG orchestrates the migratory and angiogenic activities of pericytes, indicating its potential as a target for improving reparative angiogenesis. Oct 06 2021

    Published Data

    Fig.1 A significant decrease in TPBG expression was observed in cell lines where stable silencing had been implemented.

    The western blotting analysis for TPBG expression was conducted in BxPC-3 and PANC-1 cells after TPBG knockdown, with normalization of the densitometric value to the internal control, and relative expression was determined using the equation: The normalization of the two groups divided by the first normalized value. The data were presented as the mean ± standard deviation, based on three replicates, with **P<0.01 indicating statistical significance. TPBG, trophoblast glycoprotein, and shRNA, short hairpin RNA, were utilized in the experiment.

    Ref: He, Ping, et al. "Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling." Molecular medicine reports 12.1 (2015): 503-509.

    Pubmed: 25738465

    DOI: 10.3892/mmr.2015.3412

    Research Highlights

    Jin, Yuqing. et al. "Identification and validation of potential hypoxia-related genes associated with coronary artery disease." Frontiers in physiology, 2023.
    This article discusses the effects of environmental pollution on marine life and the importance of implementing sustainable practices to protect these fragile ecosystems. It presents evidence from various studies and highlights the urgent need for action to mitigate the damaging impact of pollution on marine organisms. The paper also proposes solutions and emphasizes the role of stakeholders in promoting environmental responsibility. By raising awareness and implementing effective strategies, it is possible to create a healthier marine environment for present and future generations.
    Jin, Yuqing. et al. "Identification and validation of potential hypoxia-related genes associated with coronary artery disease." Frontiers in physiology, 2023.
    Pubmed: 37637145   DOI: 10.3389/fphys.2023.1181510

    Ye, Fangzhou. et al. "Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication." Cell death & disease, 2023.
    Breast cancer is a prevalent form of malignancy affecting women globally. Research has shown that cancer-associated fibroblasts (CAFs) play a significant role in regulating tumor progression through exosome-mediated communication. However, the exact mechanism by which exosomal circRNA from CAFs promotes breast cancer progression is not well understood. A study using high-throughput sequencing found upregulated expression of circTBPL1 in exosomes derived from breast cancer-derived CAFs compared to normal fibroblasts (NFs). Further investigation revealed that exosomal circTBPL1 could be transferred to breast cancer cells, enhancing cell proliferation, migration, and invasion. The knockdown of circTBPL1 in CAFs reduced their tumor-promoting ability. It was discovered that miR-653-5p is a target of circTBPL1, and its overexpression can reverse the malignant effects caused by exosomal circTBPL1 in breast cancer. It was also found that circTBPL1 protects the TPBG gene from degradation by miR-653-5p, ultimately leading to increased breast cancer progression. In xenograft models, the tumor-promoting role of exosomal circTBPL1 from CAFs was validated. These findings suggest that exosomal circTBPL1 derived from CAFs can contribute to breast cancer progression through the miR-653-5p/TPBG pathway, highlighting the potential of exosomal circTBPL1 as a biomarker and therapeutic target for breast cancer.
    Ye, Fangzhou. et al. "Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication." Cell death & disease, 2023.
    Pubmed: 37495592   DOI: 10.1038/s41419-023-05986-8

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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