mProX™ Human TPBG Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
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Published Data
Fig.1 A significant decrease in TPBG expression was observed in cell lines where stable silencing had been implemented.
The western blotting analysis for TPBG expression was conducted in BxPC-3 and PANC-1 cells after TPBG knockdown, with normalization of the densitometric value to the internal control, and relative expression was determined using the equation: The normalization of the two groups divided by the first normalized value. The data were presented as the mean ± standard deviation, based on three replicates, with **P<0.01 indicating statistical significance. TPBG, trophoblast glycoprotein, and shRNA, short hairpin RNA, were utilized in the experiment.
Ref: He, Ping, et al. "Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling." Molecular medicine reports 12.1 (2015): 503-509.
Pubmed: 25738465
DOI: 10.3892/mmr.2015.3412
Research Highlights
Jin, Yuqing. et al. "Identification and validation of potential hypoxia-related genes associated with coronary artery disease." Frontiers in physiology, 2023.
This article discusses the effects of environmental pollution on marine life and the importance of implementing sustainable practices to protect these fragile ecosystems. It presents evidence from various studies and highlights the urgent need for action to mitigate the damaging impact of pollution on marine organisms. The paper also proposes solutions and emphasizes the role of stakeholders in promoting environmental responsibility. By raising awareness and implementing effective strategies, it is possible to create a healthier marine environment for present and future generations.
Jin, Yuqing. et al. "Identification and validation of potential hypoxia-related genes associated with coronary artery disease." Frontiers in physiology, 2023.
Pubmed:
37637145
DOI:
10.3389/fphys.2023.1181510
Ye, Fangzhou. et al. "Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication." Cell death & disease, 2023.
Breast cancer is a prevalent form of malignancy affecting women globally. Research has shown that cancer-associated fibroblasts (CAFs) play a significant role in regulating tumor progression through exosome-mediated communication. However, the exact mechanism by which exosomal circRNA from CAFs promotes breast cancer progression is not well understood. A study using high-throughput sequencing found upregulated expression of circTBPL1 in exosomes derived from breast cancer-derived CAFs compared to normal fibroblasts (NFs). Further investigation revealed that exosomal circTBPL1 could be transferred to breast cancer cells, enhancing cell proliferation, migration, and invasion. The knockdown of circTBPL1 in CAFs reduced their tumor-promoting ability. It was discovered that miR-653-5p is a target of circTBPL1, and its overexpression can reverse the malignant effects caused by exosomal circTBPL1 in breast cancer. It was also found that circTBPL1 protects the TPBG gene from degradation by miR-653-5p, ultimately leading to increased breast cancer progression. In xenograft models, the tumor-promoting role of exosomal circTBPL1 from CAFs was validated. These findings suggest that exosomal circTBPL1 derived from CAFs can contribute to breast cancer progression through the miR-653-5p/TPBG pathway, highlighting the potential of exosomal circTBPL1 as a biomarker and therapeutic target for breast cancer.
Ye, Fangzhou. et al. "Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication." Cell death & disease, 2023.
Pubmed:
37495592
DOI:
10.1038/s41419-023-05986-8