mProX™ Human TNIK Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TNIK (Traf2- and NCK-interacting protein kinase) has various applications in different fields. In the field of metabolism, TNIK has been identified as a regulator of glucose and lipid metabolism in obesity and type 2 diabetes. Studies have shown that TNIK governs lipid and glucose homeostasis in both Drosophila and mice, and Tnik knockout mice exhibit improved lipid profiles and enhanced glucose and lipid handling. In the field of cancer research, TNIK has been found to play a role in colorectal cancer cell metastasis and papillary thyroid carcinoma. Loss of LKB1, a gene associated with colorectal cancer, leads to upregulation of TNIK, which promotes cell motility and tumor metastasis. In papillary thyroid carcinoma, TNIK expression is elevated and may contribute to carcinogenesis and progression. Additionally, TNIK has been implicated in ovarian cancer, where it is targeted by miR-5590-3p to inhibit cell proliferation and invasion through the Wnt/β-catenin signaling pathway. Finally, in the field of cardiovascular disease, TNIK deficiency in B cells does not affect atherosclerosis. These studies highlight the diverse roles of TNIK in different biological processes and diseases.