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    mProX™ Human TNFSF9 Stable Cell Line

    [CAT#: S01YF-1023-PY244]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Oncology Cell Lines

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    Product Information

    Target Family
    Oncology
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Huh-7;SMMC-7721
    Target Classification
    Oncology Cell Lines
    Target Research Area
    Cancer Research;Immunology Research
    Related Diseases
    Immunodeficiency 16; Mouth Disease
    Gene ID
    Human:8744
    UniProt ID
    Human:P41273

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TNFSF9, also known as 4-1BBL, has been investigated in various cancer types, including osteosarcoma, hepatoblastoma, hepatocellular carcinoma (HCC), and glioblastoma multiforme (GBM). In osteosarcoma, high expression of TNFSF9 is associated with poor prognosis, while low expression is correlated with an abundance of CD4+ memory-activated T cells. In hepatoblastoma, extracellular calcium ions promote cell proliferation and migration, as well as decrease sensitivity to cisplatin, through the upregulation of TNFSF9. In HCC, TNFSF9 is involved in the resistance to Lenvatinib plus anti-PD1 antibodies treatment, and its expression is associated with immune cell infiltration. In GBM, TNFSF9 is highly expressed in microglia and is identified as a potential target in the tumor microenvironment. These studies highlight the diverse roles of TNFSF9 in cancer progression and its potential as a prognostic biomarker and therapeutic target in different cancer types.

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    FAQ

    chat Cameron Davis (Verified Customer)

    What is the therapeutic potential of TNFSF9 in cancer? Jan 05 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TNFSF9 is being explored for its role in antitumor immunotherapy, particularly in enhancing T-cell responses against tumors. Jan 05 2023

    chat Jordan Smith (Verified Customer)

    How does TNFSF9 contribute to cancer metastasis? Apr 26 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TNFSF9 has been found to promote metastasis in cancers like pancreatic cancer, indicating its role in tumor progression. Apr 26 2023

    Related Products by Target
    • Magic™ Human TNFSF9 HEK293T Cell Line (CAT#: S01YF-0123-KX324)
    • mProX™ Human TNFSF9 Stable Cell Line (CAT#: S01YF-1023-PY244)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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