mProX™ Human TMEM87B Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TMEM87B is a eukaryotic transmembrane protein that has been implicated in various biological processes and diseases. It is part of the TMEM87 protein family, which includes TMEM87A and TMEM87B. TMEM87s have been proposed to have roles in protein transport to and from the Golgi, as mechanosensitive ion channels, and in developmental signaling. Disruption of TMEM87 has been associated with cancers and developmental disorders. Structural and functional analyses suggest that TMEM87A, a member of the TMEM87 protein family, may not function as an ion channel or G-protein coupled receptor. TMEM87A and other structurally related proteins, such as GPR107, GPR108, GPR180, TMEM145, TMEM181, and WLS, share a characteristic domain arrangement and could serve a common role in trafficking membrane-associated cargo. Additionally, TMEM87B has been identified as a potential target of tumor-suppressive miR-30e-3p in head and neck squamous cell carcinoma. It has also been found to be located within the 2q13 critical region associated with congenital heart defects. Further research is needed to fully understand the specific functions and implications of TMEM87B in these contexts.