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    mProX™ Human TMEM175 Stable Cell Line

    [CAT#: S01YF-1023-PY247]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;RAW264.7
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research
    Related Diseases
    Meier-Gorlin Syndrome 3; Parkinson Disease, Late-Onset
    Gene ID
    Human:84286
    UniProt ID
    Human:Q9BSA9

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TMEM175 is a lysosomal ion channel that has been associated with neurological diseases. It plays a role in maintaining lysosomal acidity and assisting in the digestion of abnormal proteins and organelles. Abnormal expression of TMEM175 has been observed in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. In a study, six ALS risk genes, including TMEM175, were identified, and the dysregulation of TMEM175 in multiple tissues was found. TMEM175 has also been implicated in Parkinson's disease (PD), with a positive correlation and causal effect observed between PD and ALS. Several single-nucleotide polymorphisms and genes, including TMEM175, have been associated with both diseases. Additionally, TMEM175 has been studied in the context of neonatal hypoxic-ischemic brain injury, where its downregulation was found to contribute to impairment of the autophagy-lysosome pathway. Overall, TMEM175 shows promise as a therapeutic target for neurodegenerative diseases, and further research is needed to explore its potential in the treatment of these conditions.

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    FAQ

    chat Alex Davis (Verified Customer)

    What is the role of TMEM175 in lysosomal function? Dec 03 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TMEM175 is a lysosomal potassium channel that maintains lysosomal pH homeostasis, crucial for cellular degradation processes and implicated in diseases like Parkinson's. Dec 03 2022

    chat Casey Jones (Verified Customer)

    How does TMEM175 contribute to neurological diseases? Sep 19 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TMEM175 dysfunction is linked to neuronal injury in conditions like cerebral ischemia-reperfusion, suggesting its role in neuroprotection and disease pathogenesis. Sep 19 2020

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    • mProX™ Human TMEM175 Stable Cell Line (CAT#: S01YF-1023-PY247)
    • Magic™ Human FLAG tagged TMEM175 HEK293T Cell Line (CAT#: S01YF-1022-KX634)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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