mProX™ Human TEC Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX501	Magic™ Human TEC in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research

Related Diseases

Transient Erythroblastopenia Of Childhood; Agammaglobulinemia, X-Linked

Gene ID

Human:7006

UniProt ID

Human:P42680

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TEC, a non-receptor tyrosine kinase, plays a pivotal role in various cellular processes, including intracellular signaling and immune cell function. In the scientific domain, TEC has been extensively studied for its involvement in B cell receptor (BCR) signaling. Specifically, TEC acts as a critical mediator in the BCR signaling pathway, which is essential for B cell development, differentiation, and function. Dysregulation of TEC and its associated signaling pathways can lead to various immunological disorders, including autoimmune diseases. Moreover, TEC has been implicated in the pathogenesis of certain cancers, such as chronic lymphocytic leukemia. The kinase's central role in immune cell signaling highlights its potential as a therapeutic target for immune-related diseases and malignancies.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human TEC Stable Cell Line (S01YF-1023-PY112). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Jordan Miller (Verified Customer)

How is TEC used in space communications? Jun 18 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Accurate prediction of ionospheric Total Electron Content (TEC) is crucial for global navigation satellite systems and space communications. Jun 18 2020

chat Taylor Miller (Verified Customer)

What is the Theory of Event Coding (TEC) in psychology? Mar 19 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TEC is a framework for understanding perception and action planning, proposing that perceptual contents and action plans are coded in a common representational medium. Mar 19 2021

Published Data

Fig.1 Tec kinase has been identified as a novel factor implicated in FGF2 secretion through RNAi-based screening.

Stable HeLa cell lines expressing FGF2-GFP under doxycycline-dependent regulation were utilized to quantify the export of FGF2 to cell surfaces via flow cytometry. Simultaneous measurement of expression levels and FGF2-GFP cell surface staining revealed that downregulation of Tec kinase did not impact expression levels but led to a significant reduction in FGF2-GFP cell surface expression, with a closely matching phenotype observed when an independent siRNA targeting Tec kinase (Tec #4) was employed (Tec #1).

Ref: Ebert, Antje D., et al. "Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion." Traffic 11.6 (2010): 813-826.

Pubmed: 20230531

DOI: 10.1111/j.1600-0854.2010.01059.x

Research Highlights

Machado, Isabel. et al. "Six-month effects of supervised exercise on walking ability and health-related factors in peripheral arterial disease: a pilot study." International angiology : a journal of the International Union of Angiology, 2023.
The effects of a six-month combined exercise program on walking ability, lower limb body composition, cardiovascular risk factors, and Ankle-Brachial Index (ABI) in peripheral arterial disease (PAD) patients with intermittent claudication (IC) were analyzed in this study. Results suggest that the program may counteract muscle loss and attenuate disease progression.
Machado, Isabel. et al. "Six-month effects of supervised exercise on walking ability and health-related factors in peripheral arterial disease: a pilot study." International angiology : a journal of the International Union of Angiology, 2023.
Pubmed: 37870494 DOI: 10.23736/S0392-9590.23.05085-X

Xiao, Shiyun. et al. "Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells." Frontiers in immunology, 2023.
Lin28 is a protein known for its important roles in embryonic development, pluripotency of stem cells, and regulation of cell proliferation and differentiation. It is expressed in endodermal epithelial cells during the early stages of development and continues to be expressed in adult epithelia, suggesting potential functions after birth. However, the specific expression and function of Lin28 in thymic epithelial cells (TECs) have not been fully studied. This research aimed to investigate the expression patterns of Lin28 in TECs and its possible involvement in TEC differentiation.
Xiao, Shiyun. et al. "Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells." Frontiers in immunology, 2023.
Pubmed: 37868985 DOI: 10.3389/fimmu.2023.1261081