mProX™ Human TAOK2 Stable Cell Line

[CAT#: S01YF-1023-PY109]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX498	Magic™ Human TAOK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;Mouse primary neurons

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Hepatocellular Carcinoma; Autism Spectrum Disorder

Gene ID

Human:9344

UniProt ID

Human:Q9UL54

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TAOK2 is a protein that has been found to play important roles in various biological processes. In the context of cancer, TAOK2 has been identified as a key modulator of the Hippo signaling pathway, which is involved in limiting tissue growth and proliferation. It binds to and phosphorylates the core kinases of the pathway, leading to the reduction of YAP1 phosphorylation and subsequent transcription of oncogenes. Reduced TAOK2 expression has been correlated with decreased patient survival time in certain types of human cancers, suggesting its role as a tumor suppressor gene. Additionally, TAOK2 has been implicated in neuropathic pain, where its activation contributes to pain hypersensitivity through the activation of the cGAS-STING signaling pathway. Furthermore, TAOK2 has been linked to neurodevelopmental disorders, as its deficiency leads to membrane sculpting deficits and aberrant neuronal morphology. Overall, targeting TAOK2 could have potential applications in modulating cell growth, combating cancer, and treating neuropathic pain and neurodevelopmental disorders.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Peyton Jones (Verified Customer)

What is the role of TAOK2 in immune response? Nov 03 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TAOK2 mutations can lead to impaired T cell proliferation upon activation, highlighting its importance in the immune response, particularly against HPV and possibly in the pathogenesis of IBD. Nov 03 2021

chat Taylor Miller (Verified Customer)

How does TAOK2 contribute to neurodevelopmental disorders? Aug 09 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TAOK2 is essential for neuronal migration and is linked to neurodevelopmental disorders, including autism spectrum disorder (ASD). Aug 09 2021

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