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    mProX™ Human TAOK1 Stable Cell Line

    [CAT#: S01YF-1023-PY108]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Host Cell Type:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1222-KX497 Magic™ Human TAOK1 in Vitro Assay Human Kinase Assay

    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    Kinase Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Developmental Delay With Or Without Intellectual Impairment Or Behavioral Abnormalities; Global Developmental Delay With Or Without Impaired Intellectual Development
    Gene ID
    Human:57551
    UniProt ID
    Human:Q7L7X3

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TAOK1, or thousand and one amino acid kinase 1, is associated with various neurodevelopmental disorders and conditions. One study found that TAOK1 mutations were linked to fetal macrocephaly in the third trimester, indicating its role in prenatal neurodevelopmental disorders. Another study discovered that TAOK1 haploinsufficiency led to autistic-like behaviors in mice, suggesting its involvement in autism spectrum disorder (ASD). Additionally, TAOK1 was found to regulate social interaction behaviors through its influence in the dorsal raphe nucleus (DRN), providing insights into the etiology of ASD. Furthermore, TAOK1 was identified as a potential therapeutic target for preventing and treating premature white matter injury, a common consequence of preterm birth. Finally, another study demonstrated that inhibiting TAOK1 could ameliorate muscle atrophy in cancer cachexia, suggesting its involvement in muscle wasting conditions. Overall, TAOK1 plays a crucial role in neurodevelopment, social behaviors, white matter injury, and muscle atrophy.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human TAOK1 Stable Cell Line (S01YF-1023-PY108). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Jordan Miller (Verified Customer)

    What is the association between TAOK1 and neurodevelopmental disorders? Sep 09 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Variants in TAOK1 are associated with a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and other symptoms. Sep 09 2021

    chat Taylor Smith (Verified Customer)

    How does TAOK1 affect neuronal maturation and cortical development? Jun 19 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TAOK1 is essential for neuronal maturation and cortical development, with dysregulation leading to neurodevelopmental disorders. Jun 19 2020

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    • mProX™ Human TAOK1 Stable Cell Line (CAT#: S01YF-1023-PY108)
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