mProX™ Human SYK Stable Cell Line

[CAT#: S01YF-1023-PY107]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX496	Magic™ Human SYK in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MCF-10A;MCF10DCIS.com;MCF-10A-neoT

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research

Related Diseases

Immunodeficiency 82 With Systemic Inflammation; Arthritis

Gene ID

Human:6850

UniProt ID

Human:P43405

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The applications of SYK (spleen tyrosine kinase) include its role in boosting anti-tumor activity of CD8(+) T cells in cancer immunotherapy, its involvement in inhibiting platelet aggregation and glycoprotein IIb/IIIa expression, its contribution to the formation of neutrophil extracellular traps in acute pancreatitis, its inhibition of platelet activation stimulated by collagen, and its activation of glycoprotein receptors GPVI, CLEC-2, and PEAR1 in human platelets. These findings suggest that targeting SYK could have potential therapeutic implications in cancer treatment, cardiovascular diseases, and thrombotic diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Williams (Verified Customer)

How does SYK contribute to immune dysregulation and systemic inflammation? Apr 05 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation, suggesting potential treatments with bone marrow transplantation or SYK inhibitors. Apr 05 2021

chat Cameron Smith (Verified Customer)

What is the role of SYK in acute kidney injury? Dec 12 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Quercetin protects against cisplatin-induced acute kidney injury by inhibiting the Mincle/Syk/NF-κB signaling pathway, reducing inflammation. Dec 12 2020

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