mProX™ Human STK38L Stable Cell Line

[CAT#: S01YF-1023-PY22]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX397	Magic™ Human NDR2(STK38L) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

Kinase Cell Lines

Target Research Area

Ocular Research;CNS Research

Related Diseases

Warburg Micro Syndrome 1; Ossification Of The Posterior Longitudinal Ligament Of Spine

Gene ID

Human:23012

UniProt ID

Human:Q9Y2H1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

STK38L is implicated in various medical conditions and biological processes. It is identified as a candidate gene for intellectual disability and Kallmann syndrome, a disorder characterized by impaired sexual development and a lack of sense of smell. STK38L is also involved in neurodevelopmental disorders, including cognitive impairments. Additionally, STK38L plays a role in maintaining innate antiviral immunity by regulating the phosphorylation of IRF3, a key protein in the immune response to viral infections. It is also associated with the regulation of cell proliferation, differentiation, migration, and homeostasis in the ocular and central nervous system. The gene's expression pattern in relevant human tissues further supports its involvement in these processes. However, further research is needed to confirm its causal role and the extent of its contributions to these conditions and biological mechanisms.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Smith (Verified Customer)

How does STK38L influence autophagy? Jul 05 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

During starvation-induced autophagy, STK38L is activated and phosphorylates ULK1, affecting its state and function in autophagy. Jul 05 2021

chat Skyler Garcia (Verified Customer)

What is the effect of STK38L depletion in cancer cells? Sep 24 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

RNAi-mediated depletion of STK38L in specific cancer cell lines inhibits cellular proliferation and induces apoptosis, with increased expression of LATS2 kinase and the cell cycle regulator p21. Sep 24 2021

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