mProX™ Human STK38 Stable Cell Line

[CAT#: S01YF-1023-PY21]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX396	Magic™ Human NDR1(STK38) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;ST486

Target Classification

Kinase Cell Lines

Gene ID

Human:11329

UniProt ID

Human:Q15208

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

STK38 has been identified as a key component in various biological processes and diseases. In colorectal cancer, STK38 interacts with NLRP12 to downregulate the Wnt/Œ≤-catenin pathway, suppressing tumor growth. In triple-negative breast cancer, STK38 is involved in promoting tumor growth by disrupting the binding of proteins involved in ubiquitination and degradation. STK38 also plays a role in preeclampsia, where its activation is related to immune infiltration and necroptosis. Additionally, STK38 is implicated in the DNA damage response and can be targeted for radio-sensitization. In nonalcoholic fatty liver disease, the induction of STK38 by a high-fat diet leads to proinflammation, insulin resistance, and intrahepatic lipid accumulation. These studies highlight the diverse applications of STK38 in cancer, pregnancy-related complications, and liver diseases, providing potential therapeutic targets for intervention.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jordan Davis (Verified Customer)

What are the primary functions of STK38 in cellular processes? Jan 01 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

STK38, also known as NDR1, is a Hippo pathway serine/threonine protein kinase with diverse functions in normal and cancer cells. It plays a crucial role in modulating partnerships with different proteins depending on the cellular context and regulates nuclear export of various proteins. Jan 01 2020

chat Jordan Garcia (Verified Customer)

How does STK38 influence autophagy? Oct 24 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

STK38 modulates its partnership with cytoplasmic proteins during nutrient starvation-induced autophagy, showcasing its involvement in this crucial cellular process. Oct 24 2020

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