mProX™ Human STK25 Stable Cell Line

Schmidt, Frank. et al. "Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system." Frontiers in physiology, 2023.
The authors used a high-throughput protein array to screen autoantibody responses in two cohorts of COVID-19 patients from Qatar and New York. They found elevated autoantibody responses against several proteins, especially SPANXN4 and STK25, which are related to the male reproductive system. They suggested that SPANXN4 and STK25 may be involved in COVID-19-associated complications in the male reproductive tract and proposed targeting their pathway as a possible therapy.
Schmidt, Frank. et al. "Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system." Frontiers in physiology, 2023.
Pubmed: 37520825   DOI: 10.3389/fphys.2023.1203723

Mao, Yang. et al. "Comparative genomics studies on the stk gene family in vertebrates: From the bighead carp (Hypophthalmichthys nobilis) genome." Fish & shellfish immunology, 2023.
The mammalian sterile 20-like (MST) family, a member of the serine/threonine protein kinase (STK) superfamily, plays a crucial role in various biological processes such as cell apoptosis, polarity, migration, immune regulation, inflammatory responses, and cancer. In the bighead carp (Hypophthalmichthys nobilis), an economically important fish species, the STK gene family and its immune-related functions hold potential for enhancing economic yield. However, the comprehensive understanding of STKs in bighead carp is lacking. This study, divided the five stk sequences from bighead carp into two classes: stk3/4 and stk24/25/26. Through gene structure and motif prediction analyses, stk was determined to be conserved in bighead carp. Teleosts, including bighead carp, have more stk members due to teleost-specific whole-genome duplication compared to 26 other vertebrate species. Synteny analysis revealed that stk3, stk24, stk25, and stk26 have remained relatively conserved during evolution in bighead carp, while stk4 has been lost in most Cyprinid species, including bighead carp. RNA-seq data showed that STK expression was influenced by various pathogens, and the expression of these STKs (Hnstk3, Hnstk24a, Hnstk24b, Hnstk25, and Hnstk26) varied in seven tissues of bighead carp. Additionally, the study demonstrated that STK expression was significantly altered in the head kidney and that stk24 was involved in defense against Aeromonas hydrophila infection. This research offers a foundation for further analysis of stk function in bighead carp and can serve as a reference for future phylogenetics studies.
Mao, Yang. et al. "Comparative genomics studies on the stk gene family in vertebrates: From the bighead carp (Hypophthalmichthys nobilis) genome." Fish & shellfish immunology, 2023.
Pubmed: 36858329   DOI: 10.1016/j.fsi.2023.108642