mProX™ Human SRPK3 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SRPK3 is involved in various biological processes and has applications in different fields of research. In the context of chronic kidney disease (CKD), SRPK3 is upregulated and associated with immune and vascular cell differentiation in veins, fibrogenic processes, and protein kinase signal transduction pathways. It is also implicated in embryonic organ development, positive regulation of developmental growth, and muscle structure development in veins. In another study, SRPK3 is identified as a causative gene for X-linked intellectual disability (XLID) and is associated with eye movement defects. Additionally, SRPK3 is involved in the pathogenesis of Parkinson's disease, where its decreased expression is associated with increased α-synuclein levels in the substantia nigra. In a rat model, prolactin is shown to have protective effects against motor and memory deficits induced by 1,2-Diacetylbenzene (DAB), and the underlying mechanisms involve the upregulation of SRPK3. These findings highlight the diverse roles and potential therapeutic applications of SRPK3 in different diseases and conditions.