mProX™ Human SRPK2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SRPK2 (serine/arginine-rich protein kinase 2) has various applications in different fields. In the field of cell growth and metabolism, SRPK2 is involved in the coupling of transcription and splicing of lipogenesis enzymes downstream of mTORC1 signaling, promoting fatty acid synthesis and cancer cell proliferation. In the study of brain regional vulnerability to aging, SRPK2 is identified as a key regulator of alternative splicing and gene expression in different brain regions, contributing to gender differences in developing neurodegenerative diseases such as Alzheimer's disease. In the context of alcohol-associated liver disease (ALD), SRPK2 plays a role in regulating alternative splicing of lipid metabolism genes, and targeting SRPK2 signaling may offer potential therapeutic approaches to combat ALD. Additionally, in lung adenocarcinoma, CCNB1 (cyclin B1), a protein regulated by SRPK2, is identified as an independent prognostic factor, and SRPK2 may affect the expression of genes involved in different pathways in LUAD. Overall, SRPK2 has diverse applications in cell growth, brain aging, liver disease, and cancer research.